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2e). A physiologically suitable IgE concentration of twelve.five nM (Supplementary Fig. second) was pre-incubated with ligelizumab or omalizumab IgG in various concentrations. In settlement Together with the ELISA information, we noticed weaker inhibition of IgE-binding to CD23 on RPMI8866 cells with ligelizumab than with omalizumab (Fig. 2f). Thus, the two anti-IgE antibodies reveal a qualitatively distinctive inhibition profile for The 2 IgE receptor pathways with ligelizumab currently being more strong and even more selective for inhibition of IgE binding to FcεRI.
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